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Letting go differs from giving up and abandoning hope
By "letting go", we mean casting off our attachments, not "giving up". We should face up to our problems, do our best to deal with them, then irrespective of success or failure, just let them go.
(Source: GDD-707)
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The Virtuous Self at Its Highest Level---the True Self
Learn to endeavor and put in efforts while remaining adaptive, flexible, and unattached. This is the practice of no-self.